Protein Details: Neuronal acetylcholine receptor subunit beta-2

Protein ID

ICDB_Pro_0368

Protein Name

Neuronal acetylcholine receptor subunit beta-2

Gene Name

CHRNB2

Organism

Homo sapiens (Human)

Length

502 amino acids

AlphaFoldDB

AF-P17787-F1-model_v4.pdb

Function

After binding acetylcholine;the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. .

Sequence

MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSK

PDB Structures

2K58 2K59 2KSR 2LM2 5KXI 6CNJ 6CNK 6UR8 6USF

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 84: "Key residue that may interfere with effective access of the conotoxin BuIA to the channel binding site"; SITE 136: "Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA"; SITE 144: "Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA"

Disease

Epilepsy;Nocturnal Frontal Lobe;3 and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

Location

DOI ID

10.1093/nar/18.14.4272; 10.1007/bf02736842; 10.1016/s0014-5793(96)01383-x; 10.1007/s004390050885; 10.1007/s003359901111; 10.1101/gr.2596504; 10.1021/bi048918g; 10.1124/mol.105.017459; 10.1111/jnc.13718; 10.1073/pnas.1602619113; 10.1016/j.bbamem.2010.04.014; 10.1016/j.bbamem.2012.02.008; 10.1038/81566; 10.1086/316946; 10.1080/14622200110098419

RefSeq

NP_000739.1